Performance and Reliability Study and Exploration of NAND Flash-based Solid State Drives

The research that stems from my doctoral dissertation focuses on addressing essential challenges in developing techniques that utilize solid-state memory technologies (with emphasis on NAND flash memory) from device, circuit, architecture, and system perspectives in order to exploit their true potential for improving I/O performance in high-performance computing systems. These challenges include not only the performance quirks arising from the physical nature of NAND flash memory, e.g., the inability to modify data in-place, read/write performance asymmetry, and slow and constrained erase functionality, but also the reliability drawbacks that limits solid state drives (SSDs) from widely deployed. To address these challenges, I have proposed, analyzed, and evaluated the I/O scheduling schemes, strategies for storage space virtualization, and data protection methods, to boost the performance and reliability of SSDs

Reducing SSD Read Latency via NAND Flash Program and Erase Suspension

Abstract In NAND flash memory, once a page program or block erase (P/E) command is issued to a NAND flash chip, the subsequent read requests have to wait until the timeconsuming P/E operation to complete. Preliminary results show that the lengthy P/E operations may increase the read latency by 2x on average. As NAND flashbased SSDs enter the enterprise server storage, this increased read latency caused by the contention may significantly degrade the overall system performance. Inspired by the internal mechanism of NAND flash P/E algorithms, we propose in this paper a low-overhead P/E suspension scheme, which suspends the on-going P/E to service pending reads and resumes the suspended P/E afterwards. In our experiments, we simulate a realistic SSD model that adopts multi-chip/channel and evaluate both SLC and MLC NAND flash as storage materials of diverse performance. Our experimental results show that the proposed technique achieves a near-optimal performance gain on servicing read requests. Specifically, the read latency is reduced on average by 50.5% compared to RPS and 75.4% compared to FIFO at cost of less than 4% overhead on write requests

Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect

We designed and synthesized homochiral-peptide-based boron diketonate complexes. Co-administration of the two stereoisomers in cancer cells led to molecular assembly targeting both the plasma membrane and the lysosomes mediated via membrane-bonded enzymes. The dual-targeted-assembly generates a synergistic anticancer effect with amplified cancer spheroid toxicity and enhanced inhibition efficacy on cancer cell migration

A Subset of CXCR5+CD8+ T Cells in the Germinal Centers From Human Tonsils and Lymph Nodes Help B Cells Produce Immunoglobulins

Recent studies indicated that CXCR5+CD8+ T cells in lymph nodes could eradicate virus-infected target cells. However, in the current study we found that a subset of CXCR5+CD8+ T cells in the germinal centers from human tonsils or lymph nodes are predominately memory cells that express CD45RO and CD27. The involvement of CXCR5+CD8+ T cells in humoral immune responses is suggested by their localization in B cell follicles and by the concomitant expression of costimulatory molecules, including CD40L and ICOS after activation. In addition, CXCR5+CD8+ memory T cells produced significantly higher levels of IL-21, IFN-γ, and IL-4 at mRNA and protein levels compared to CXCR5−CD8+ memory T cells, but IL-21-expressing CXCR5+CD8+ T cells did not express Granzyme B and perforin. When cocultured with sorted B cells, sorted CXCR5+CD8+ T cells promoted the production of antibodies compared to sorted CXCR5−CD8+ T cells. However, fixed CD8+ T cells failed to help B cells and the neutralyzing antibodies against IL-21 or CD40L inhibited the promoting effects of sorted CXCR5+CD8+ T cells on B cells for the production of antibodies. Finally, we found that in the germinal centers of lymph nodes from HIV-infected patients contained more CXCR5+CD8+ T cells compared to normal lymph nodes. Due to their versatile functional capacities, CXCR5+CD8+ T cells are promising candidate cells for immune therapies, particularly when CD4+ T cell help are limited

Boosting with an aerosolized Ad5-nCoV elicited robust immune responses in inactivated COVID-19 vaccines recipients

IntroductionThe SARS-CoV-2 Omicron variant has become the dominant SARS-CoV-2 variant and exhibits immune escape to current COVID-19 vaccines, the further boosting strategies are required.MethodsWe have conducted a non-randomized, open-label and parallel-controlled phase 4 trial to evaluate the magnitude and longevity of immune responses to booster vaccination with intramuscular adenovirus vectored vaccine (Ad5-nCoV), aerosolized Ad5-nCoV, a recombinant protein subunit vaccine (ZF2001) or homologous inactivated vaccine (CoronaVac) in those who received two doses of inactivated COVID-19 vaccines. ResultsThe aerosolized Ad5-nCoV induced the most robust and long-lasting neutralizing activity against Omicron variant and IFNg T-cell response among all the boosters, with a distinct mucosal immune response. SARS-CoV-2-specific mucosal IgA response was substantially generated in subjects boosted with the aerosolized Ad5-nCoV at day 14 post-vaccination. At month 6, participants boosted with the aerosolized Ad5-nCoV had remarkably higher median titer and seroconversion of the Omicron BA.4/5-specific neutralizing antibody than those who received other boosters. DiscussionOur findings suggest that aerosolized Ad5-nCoV may provide an efficient alternative in response to the spread of the Omicron BA.4/5 variant.Clinical trial registrationhttps://www.chictr.org.cn/showproj.html?proj=152729, identifier ChiCTR2200057278

BPAC: An Adaptive Write Buffer Management Scheme for Flash-based Solid State Drives

Abstract—Solid State Drives (SSD’s) have shown promise to be a candidate to replace traditional hard disk drives, but due to certain physical characteristics of NAND flash, there are some challenging areas of improvement and further research. We focus on the layout and management of the small amount of RAM that serves as a cache between the SSD and the system that uses it. Of the techniques that have previously been proposed to manage this cache, we identify several sources of inefficient cache space management due to the way pages are clustered in blocks and the limited replacement policy. We develop a hybrid page/block architecture along with an advanced replacement policy, called BPAC, or Block-Page Adaptive Cache, to exploit both temporal and spatial locality. Our technique involves adaptively partitioning the SSD on-disk cache to separately hold pages with high temporal locality in a page list and clusters of pages with low temporal but high spatial locality in a block list. We run trace-driven simulations to verify our design and find that it outperforms other popular flash-aware cache schemes under different workloads. I

Underwater Target Detection and 3D Reconstruction System Based on Binocular Vision

To better solve the problem of target detection in marine environment and to deal with the difficulty of 3D reconstruction of underwater target, a binocular vision-based underwater target detection and 3D reconstruction system is proposed in this paper. Two optical sensors are used as the vision of the system. Firstly, denoising and color restoration are performed on the image sequence acquired by the vision of the system and the underwater target is segmented and extracted according to the image saliency using the super-pixel segmentation method. Secondly, aiming to reduce mismatch, we improve the semi-global stereo matching method by strictly constraining the matching in the valid target area and then optimizing the basic disparity map within each super-pixel area using the least squares fitting interpolation method. Finally, based on the optimized disparity map, triangulation principle is used to calculate the three-dimensional data of the target and the 3D structure and color information of the target can be given by MeshLab. The experimental results show that for a specific size underwater target, the system can achieve higher measurement accuracy and better 3D reconstruction effect within a suitable distance